Lovenox (Enoxaparin) - Side Effects, Dosage, Interactions. Lovenox is the brand name for enoxaparin, a blood- thinning or anticoagulant drug used to prevent and treat blood clots. Lovenox is often used to prevent blood clots in the legs, known as deep venous thrombosis (DVT). In DVT, the clots can travel from the legs to the lungs and can be life- threatening. Lovenox is also used to prevent blood clots after hip or knee replacement surgery or abdominal surgery. During these post- op times, clots are most likely to form. The medicine is also used to prevent blood clots in the heart arteries during heart attacks. Besides being used as a preventive medicine, Lovenox is also used to treat DVT once it occurs, sometimes together with a blood thinner, warfarin (Coumadin). The Food and Drug Administration (FDA) approved Lovenox, made by Sanofi, in 1. The drug is made from heparin, which is a blood thinner, and includes an active ingredient made up of a complex mixture of sugar molecules. In 2. 01. 0, the FDA approved the first generic version of the drug, made by Sandoz Inc. Lovenox is injected subcutaneously or given intravenously (IV).
Lovenox Warnings. Lovenox carries a black- box warning explaining that its use in patients who have spinal or epidural anesthesia or spinal puncture carries an increased risk of bleeding and bruising. This bleeding and bruising may lead to long- term or permanent paralysis. If you are on Lovenox, you will need to have blood tests periodically to see how well it is working. Every doctor or dentist you go to should know you are taking Lovenox. If you are about to have a medical or dental procedure, ask if you should discontinue Lovenox beforehand. The medicine carries a risk of bleeding problems even if you don't have anesthesia or a spinal puncture. If you notice any unusual bleeding, or bruising, tell your doctor. Ask your dentist how best to clean your teeth and gums so you don't experience excessive bleeding. If you fall, have a blow to the head or your body, or have recently had a baby, be sure your primary doctor knows. All of these events could increase the risk of excess bleeding while on Lovenox. Be sure your doctor knows all your medicines. Don't start a new one, even an over- the- counter (OTC) medicine, vitamin or herbal medicine, without your doctor's approval. When used by patients with mechanical heart valves, the blood thinner Pradaxa raises the risk of both dangerous clots and bleeding around the heart, a new study says. Eliquis Prices, Coupons and Patient Assistance Programs. Eliquis (apixaban) is a member of the factor Xa inhibitors drug class and is commonly used for Deep Vein. Pregnancy and Lovenox. Lovenox is in Pregnancy Category B, according to the FDA, meaning that animal studies have not revealed evidence of harm to the developing baby but no adequate studies have been done in pregnant women. Talk to your doctor about whether it’s safe to take Lovenox while pregnant. No adequate studies have been done on the use of Lovenox while breastfeeding. Ask your doctor whether it’s safe to breastfeed while taking it. Side Effects, FDA Black Box Warning & Interactions. There are a number of other blood thinners currently on the market. Some are in the same class as Xarelto and others work differently and have different side effects. All blood thinners carry the risk of bleeding, however. In clinical trials, researchers compare the newer drugs to warfarin for effectiveness and safety. These are some of the most popular blood thinners and how they compare to Xarelto. Pradaxa. Another better- known oral anticoagulant is the drug Pradaxa (dabigatran etexilate), manufactured by Bayer’s competitor, Boehringer- Ingelheim. Xarelto and Pradaxa are similar, but they work in different ways. Xarelto inhibits a protein involved in the coagulation process called Factor Xa, which interrupts the blood- clotting process and prevents another protein, thrombin, from forming. Pradaxa directly inhibits thrombin from forming. Before the FDA developed a Pradaxa bleeding antidote called Praxbind in 2. Boehringer- Ingelheim spent hundreds of millions to settle thousands of bleeding lawsuits linked to the medication. Coumadin (warfarin)For decades, warfarin — also known by the brand names Coumadin and Jantoven — was the standard of care for preventing blood clots. Unlike Xarelto, patients must make frequent visits to the doctor for blood tests and dosage adjustments. There are also dietary restrictions for people who take this drug. In 2. 01. 1, the New England Journal of Medicine published the results of the ROCKET AF study that compared Xarelto to warfarin in patients with AF. The FDA said the study failed to show that Xarelto was more effective than warfarin. Xarelto is also known to cause more abdominal bleeding than warfarin. But warfarin caused more brain bleeding. Eliquis. Like Xarelto, Eliquis (apixaban) is a Factor Xa inhibitor and works the same way to stop clots from forming. The FDA approved it a year after Xarelto, and it lacks an antidote for major bleeding. But, in the clinical trial, ARISOTLE, it showed a 3. Both of these numbers are superior to Xarelto.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
July 2017
Categories |